High-Dose Micafungin in Neonates and Young Infants with Invasive Candidiasis: Results of a Phase 2 Study

Author:

Auriti Cinzia1ORCID,Goffredo Bianca M.2,Ronchetti Maria P.1,Piersigilli Fiammetta1,Cairoli Sara2,Bersani Iliana1,Dotta Andrea1,Bagolan Pietro3,Pai Manjunath P.4ORCID

Affiliation:

1. Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy

2. Biochemistry Laboratory, Department of Specialist Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy

3. Neonatal Surgical Unit, Bambino Gesù Children's Hospital, Rome, Italy

4. Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Limited data are available on the most appropriate dosing, efficacy, and safety of micafungin in neonates with invasive candidiasis (IC). This study evaluated plasma levels, efficacy, and safety of micafungin at a dose of 8 mg/kg daily for a mean of 13.3 days (±5.2 days) in 35 neonates and young infants with IC.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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