Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins

Author:

Kosugi Yusuke12,Uriu Keiya34,Suzuki Narumi35,Yamamoto Keisuke16,Nagaoka Shumpei137,Kimura Izumi123,Konno Yoriyuki137,Aso Hirofumi123,Willett Brian J.8,Kobayashi Tomoko9,Koyanagi Yoshio126,Ueda Mahoko Takahashi10,Ito Jumpei13,Sato Kei1311ORCID

Affiliation:

1. Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

2. Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

3. Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan

4. Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

5. Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan

6. Graduate School of Medicine, Kyoto University, Kyoto, Japan

7. Graduate School of Biostudies, Kyoto University, Kyoto, Japan

8. MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

9. Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, Kanagawa, Japan

10. Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

11. CREST, Japan Science and Technology Agency, Saitama, Japan

Abstract

Most of the emergences of new virus infections originate from the cross-species transmission of viruses. The fact that some virus infections are strictly specific for the host species indicates that certain “species barriers” in the hosts restrict cross-species jump of viruses, while viruses have evolutionary acquired their own “arms” to overcome/antagonize/neutralize these hurdles.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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