Viruses in Vietnamese Patients Presenting with Community-Acquired Sepsis of Unknown Cause-Reference-Cited by-同舟云学术

Viruses in Vietnamese Patients Presenting with Community-Acquired Sepsis of Unknown Cause

Published:2019-09 Issue:9 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Anh Nguyen To¹,Hong Nguyen Thi Thu¹,Nhu Le Nguyen Truc¹,Thanh Tran Tan¹,Lau Chuen-Yen²,Limmathurotsakul Direk³⁴,Deng Xutao⁵⁶,Rahman Motiur¹^ORCID,Chau Nguyen Van Vinh⁷,van Doorn H. Rogier¹³,Thwaites Guy¹³,Delwart Eric⁵⁶^ORCID,Tan Le Van¹

Affiliation:

1. Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

2. Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

4. Mahidol Oxford Tropical Research Unit, Bangkok, Thailand

5. Blood Systems Research Institute, San Francisco, California, USA

6. Department of Laboratory Medicine, University of California, San Francisco, California, USA

7. Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Abstract

Community-acquired (CA) sepsis is a major public health problem worldwide, yet the etiology remains unknown for >50% of the patients. Here we applied metagenomic next-generation sequencing (mNGS) to characterize the human virome in 492 clinical samples (384 sera, 92 pooled nasal and throat swabs, 10 stools, and 6 cerebrospinal fluid samples) from 386 patients (213 adults and 173 children) presenting with CA sepsis who were recruited from 6 hospitals across Vietnam between 2013 and 2015.

Funder

Wellcome Trust of Great Britain

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00386-19

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