A Hypothesis-Generating Study of the Combination of Aspirin plus Macrolides in Patients with Severe Community-Acquired Pneumonia

Author:

Falcone Marco1,Russo Alessandro2,Shindo Yuichiro3,Farcomeni Alessio4,Pieralli Filippo5,Cangemi Roberto6,Liu Jinliang7,Xia Jingyan8,Okumura Junya3,Sano Masahiro3,Jones Christopher9,Vannucchi Vieri5,Mancone Massimo10,Micek Scott11,Xu Feng7,Violi Francesco6,Kollef Marin9

Affiliation:

1. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

2. Infectious Diseases Division, Department of Medicine, University of Udine, Udine, Italy

3. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

4. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy

5. Internal and Emergency Medicine Unit, Careggi University Hospital, Florence, Italy

6. Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy

7. Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

8. Department of Oncology Radiation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

9. Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

10. Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology, and Geriatric Sciences, Sapienza University of Rome, Rome, Italy

11. Center for Health Outcomes Research and Education, St. Louis College of Pharmacy, St. Louis, Missouri, USA

Abstract

While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of conventional antibiotic therapy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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