Characterization of Pathogenic CD8 + T cells in Chlamydia-Infected OT1 Mice-Reference-Cited by-全球学者库

Characterization of Pathogenic CD8 + T cells in Chlamydia-Infected OT1 Mice

Published:2022-01-25 Issue:1 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zhou Zengzi¹²,Tian Qi³,Wang Luying¹,Sun Xin¹,Zhang Nu²,Xue Min¹,Xu Dabao¹,Zhong Guangming²^ORCID

Affiliation:

1. The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China

2. Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, Texas, USA

3. Department of Medical Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan, China

Abstract

Chlamydia trachomatis is a leading infectious cause of infertility in women due to its induction of lasting pathology such as hydrosalpinx. Chlamydia muridarum induces mouse hydrosalpinx because C. muridarum can both invade tubal epithelia directly (as a first hit) and induce lymphocytes to promote hydrosalpinx indirectly (as a second hit). In the current study, a critical role of CD8 + T cells in chlamydial induction of hydrosalpinx was validated in both wild type C57BL/6J mice and OT1 transgenic mice.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00453-21

Reference48 articles.

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