Multicenter study to assess the use of BL-DetecTool for the detection of CTX-M-type ESBLs and carbapenemases directly from clinical specimens

Author:

Fernandez-Pittol Mariana12ORCID,Bosch Jordi12,Ballesté-Delpierre Clara3,Gonzalez Camille4,Vasilakopoulou Alexandra5,Berbel Dàmaris6,Riccobono Eleonora78,Gatermann Sören9,Kamotsay Katalin10,Reissier Sophie11,Szabo Dora12,Aszalos Albert Zoltan13,Francius Laura14,Volland Hervé15,Stankov-Pugès Milovan14,Rosenmöller Magda16,Naas Thierry4ORCID,Vila Jordi121718ORCID

Affiliation:

1. Department of Microbiology, Hospital Clinic of Barcelona, Barcelona, Spain

2. Institute for Global Health (ISGlobal), University of Barcelona, Barcelona, Spain

3. CIBER de Enfermedades Infecciosas (CIBERINFEC), ISCIII, Barcelona, Madrid, Spain

4. Team "Resist", INSERM Unit 1184, Faculty of Medicine, Université Paris-Saclay, Bacteriology-Hygiene Unit, Assistance Publique-Hôpitaux de Paris, AP-HP Paris-Saclay, Bicêtre Hospital Le Kremlin-Bicêtre, Le Kremlin-Bicêtre, France

5. Laboratory of Clinical Microbiology, Attikon University General Hospital, Medical School, National Kapodistrian University Athens (Greece), Athens, Greece

6. Microbiology Department, Hospital de Bellvitge. IDIBELL. UB. CIBERES, Barcelona, Spain

7. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

8. Department of Medical Biotechnologies, University of Siena, Siena, Italy

9. German National Reference Laboratory for Multidrug-Resistant Gram-negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Germany - (Germany), Bochum, Germany

10. Central Microbiology Laboratory, Central Hospital of Southern Pest National Institute of Hematology and Infectious Disease, Budapest, Hungary

11. Department of Bacteriology, Amiens University Hospital, Amiens, France

12. Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary

13. Health Services Management Training Centre, Semmelweis University, Budapest, Hungary

14. R&D Department, NG Biotech, Guipry, France

15. Département Médicaments et Technologies pour la Santé (DMTS), Université Paris Saclay, CEA, INRAE, SPI, Gif-sur-Yvette, France

16. IESE Bussiness School, Barcelona, Spain

17. Department of Clinical Microbiology - CDB, University of Barcelona, Hospital Clínic, Barcelona, Spain

18. CIBER de Enfermedades Infecciosas , Barcelona, Spain

Abstract

The assessed rapid assay to detect CTX-M beta-lactamases and carbapenemases directly from clinical samples can favor in the rapid detection of these mechanisms of resistance and hence the administration of a more adequate antimicrobial treatment.

Funder

Fundación Carmen y Severo Ochoa

MEC | Instituto de Salud Carlos III

Agency for Management and Research Grants of Catalan Goverment

EC | H2020 | EIT | EIT Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference23 articles.

1. Bold steps to tackle resistance

2. WHO Geneva. 2017. Global action plan on antimicrobial resistance, p 1–28. World Heal Organ.

3. Organization E center for DP and C and WH. 2023. Antimicrobial resistance surveillance in Europe 2023 - 2021 data. European Centre for Disease Prevention and Control and World Health Organization, Stockholm.

4. Crisis in Infectious Diseases: 2 Decades Later

5. Antimicrobial resistance: a One Health perspective

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