Reactivity of Antibodies from Syphilis Patients to a Protein Array Representing the Treponema pallidum Proteome

Author:

Brinkman Mary Beth1,McKevitt Matthew1,McLoughlin Melanie2,Perez Carla1,Howell Jerrilyn2,Weinstock George M.3,Norris Steven J.24,Palzkill Timothy1

Affiliation:

1. Department of Molecular Virology and Microbiology

2. Department of Pathology and Laboratory Medicine

3. Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza

4. Department of Microbiology and Molecular Genetics, University of Texas—Houston Medical School, 6431 Fannin Street, Houston, Texas 77030

Abstract

ABSTRACT To identify antigens important in the human immune response to syphilis, the serum antibody reactivity of syphilitic patients was examined with 908 of the 1,039 proteins in the proteome of Treponema pallidum subsp. pallidum using a protein array enzyme-linked immunosorbent assay. Thirty-four proteins exhibited significant reactivity when assayed with human sera from patients in the early latent stage of syphilis. A subset of antigens identified were further scrutinized for antibody reactivity at primary, secondary, and latent disease stages, and the results demonstrate that the humoral immune response to individual T. pallidum proteins develops at different rates during the time course of infection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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