Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes-Reference-Cited by-同舟云学术

Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes

Published:1994-01 Issue:1 Volume:38 Page:126-129
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alfieri C¹,Allison A C¹,Kieff E¹

Affiliation:

1. Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.

Abstract

The effect of mycophenolic acid (MPA) on the growth of Epstein-Barr virus (EBV)-transformed B cells and on EBV lytic-cycle gene expression was investigated. MPA inhibited the proliferation of newly infected or established EBV-transformed B-cell lines but was not able to block cell growth transformation or the viral lytic cycle. These results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.1.126

Reference27 articles.

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