Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay-Reference-Cited by-同舟云学术

Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

Published:2018-12 Issue:12 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wei Xia-Fei¹²,Gan Chun-Yang¹,Cui Jing¹,Luo Ying-Ying¹,Cai Xue-Fei¹,Yuan Yi¹,Shen Jing¹,Li Zhi-Ying¹,Zhang Wen-Lu¹,Long Quan-Xin¹,Hu Yuan¹,Chen Juan¹,Tang Ni¹,Guo Haitao³,Huang Ai-Long¹²,Hu Jie-Li¹²

Affiliation:

1. Key Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), Hangzhou, China

3. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

The capsid of the hepatitis B virus is an attractive antiviral target for developing therapies against chronic hepatitis B infection. Currently available core protein allosteric modulators (CpAMs) mainly affect one of the two major types of protein-protein interactions involved in the process of capsid assembly, namely, the interaction between the core dimers.

Funder

Chongqing Education Commission

HHS | National Institutes of Health

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Chongqing Science and Technology Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01302-18