Glyceraldehyde-3-Phosphate Dehydrogenase Restricted in Cytoplasmic Location by Viral GP5 Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication via Its Glycolytic Activity

Author:

Liu Xuewei12,Liu Xing1,Bai Juan1,Gao Yanni1,Song Zhongbao1,Nauwynck Hans3,Wang Xianwei1,Yang Yuanqi1,Jiang Ping14ORCID

Affiliation:

1. Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

2. College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China

3. Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

4. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China

Abstract

PRRSV poses a severe economic threat to the pig industry. PRRSV GP5, the major viral envelope protein, plays an important role in viral infection, pathogenicity, and immunity.

Funder

National Key Program of Research and Development of China

Jiangsu Key Program of Research and Development for PRRSV

Ministry of Agriculture for Swine Disease Control

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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