Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use

Author:

Beauclair Guillaume12ORCID,Naimo Eleonora12,Dubich Tatyana3,Rückert Jessica12,Koch Sandra12,Dhingra Akshay12,Wirth Dagmar34,Schulz Thomas F.125ORCID

Affiliation:

1. Institute of Virology, Hannover Medical School, Hannover, Germany

2. German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany

3. Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany

4. Institute for Experimental Hematology, Hannover Medical School, Hannover, Germany

5. Excellence Cluster 2155 RESIST, Hannover Medical School, Hannover, Germany

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the cause of three human malignancies: Kaposi’s sarcoma, primary effusion lymphoma, and the plasma cell variant of multicentric Castleman disease. Previous research has shown that several cellular tyrosine kinases play crucial roles during several steps in the virus replication cycle.

Funder

Fondation Ernst and Margarete Wagemann

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference97 articles.

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2. HHV-8 seroprevalence: a global view

3. KSHV-induced oncogenesis

4. Kaposi's Sarcoma-Associated Herpesvirus Latent Protein LANA Interacts with HIF-1α To Upregulate RTA Expression during Hypoxia: Latency Control under Low Oxygen Conditions

5. A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency

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