Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles

Author:

Yang Luyao12,Higginbotham James N.3,Liu Liping1,Zhao Gang2,Acra Sari A.1,Peek Richard M.3,Polk D. Brent456,Li Hui2,Yan Fang1

Affiliation:

1. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Department of Gastrointestinal Cancer Biology, National Clinical Cancer Research Center, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

3. Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, USA

5. Department of Biochemistry and Molecular Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA

6. The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, USA

Abstract

The symbiotic relationship between the gut microbiome and the host provides a nutrient-rich environment for gut microbes and has beneficial effects on host health. Although the composition of the gut microbiome is known to be influenced by both host genetics and environmental factors, host effects on the activities and functions of the gut microbial communities remain poorly understood.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Crohn's and Colitis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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