Spectrum of monoclonal antibodies to coxsackievirus B-3 includes type- and group-specific antibodies

Author:

Yagi S1,Schnurr D1,Lin J1

Affiliation:

1. Viral and Rickettsial Disease Laboratory, California Department of Health Services, Berkeley 94704.

Abstract

Fifteen monoclonal antibodies (MAbs) made to coxsackievirus B-3 were tested against a panel of enteroviruses by indirect immunofluorescence. The MAbs included seven which reacted with coxsackievirus B-3 only, five which reacted with more than one enterovirus included in the panel, one which reacted with broad enteroviral specificity and did not react with any heterologous virus (group specific), and two which reacted with all enteroviruses tested and at least one heterologous virus. The group-specific MAb identified 44 of 45 clinical isolates as enteroviruses, while the two broadly reactive MAbs reacted with all 45 of the clinical isolates. These MAbs are potentially important diagnostic reagents for grouping and typing enteroviruses by indirect immunofluorescence.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference21 articles.

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5. Grandien M. M. Forsgren and A. Ehrnst. 1989. Enteroviruses and reoviruses p. 513-578. In N. J. Schmidt and R. W. Emmons (ed.) Diagnostic procedures for viral rickettsial and chlamydial infections 6th ed. American Public Health Association Washington D.C.

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