Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity

Author:

Ledala Nagender1,Malik Mishika12,Rezaul Karim1,Paveglio Sara12,Provatas Anthony3,Kiel Aaron1,Caimano Melissa145,Zhou Yanjiao46,Lindgren Jonathan1,Krasulova Kristyna7ORCID,Illes Peter7ORCID,Dvořák Zdeněk7ORCID,Kortagere Sandhya8ORCID,Kienesberger Sabine9ORCID,Cosic Amar9,Pöltl Lisa9ORCID,Zechner Ellen L.9ORCID,Ghosh Subho10,Mani Sridhar10,Radolf Justin D.1114125,Matson Adam P.1211ORCID

Affiliation:

1. Department of Pediatrics, UConn Health, Farmington, Connecticut, USA

2. Division of Neonatology, Connecticut Children’s Medical Center, Hartford, Connecticut, USA

3. Center for Environmental Sciences and Engineering, University of Connecticut, Storrs, Connecticut, USA

4. Department of Medicine, UConn Health, Farmington, Connecticut, USA

5. Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA

6. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

7. Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic

8. Department of Microbiology & Immunology, Drexel University, Philadelphia, Pennsylvania, USA

9. Institute of Molecular Biosciences, University of Graz, BioTechMed-Graz, Graz, Austria

10. Department of Medicine, Molecular Pharmacology and Genetics, Albert Einstein College of Medicine, Bronx, New York, USA

11. Department of Immunology, UConn Health, Farmington, Connecticut, USA

12. Department of Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA

Abstract

The human gut harbors a complex community of microbes, including several species and strains that could be commensals or pathogens depending on context. The specific environmental conditions under which a resident microbe changes its relationship with a host and adopts pathogenic behaviors, in many cases, remain poorly understood.

Funder

Connecticut Children's Department of Research

Connecticut Children's Stevenson Fund for Microbiome Research

Office of Assistant Secretary of Defense for Health Affairs

Czech Science Foundation

Austrian Science Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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