Affiliation:
1. Division of Molecular Genetics and Centre of Biomedical Genetics
2. Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Abstract
ABSTRACT
The
Pim
family of proto-oncogenes encodes a distinct class of serine/threonine kinases consisting of PIM1, PIM2, and PIM3. Although the
Pim
genes are evolutionarily highly conserved, the contribution of PIM proteins to mammalian development is unclear. PIM1-deficient mice were previously described but showed only minor phenotypic aberrations. To assess the role of PIM proteins in mammalian physiology, compound
Pim
knockout mice were generated. Mice lacking expression of
Pim1
,
Pim2
, and
Pim3
are viable and fertile. However, PIM-deficient mice show a profound reduction in body size at birth and throughout postnatal life. In addition, the in vitro response of distinct hematopoietic cell populations to growth factors is severely impaired. In particular, PIM proteins are required for the efficient proliferation of peripheral T lymphocytes mediated by synergistic T-cell receptor and interleukin-2 signaling. These results indicate that members of the PIM family of proteins are important but dispensable factors for growth factor signaling.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
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