Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins-Reference-Cited by-同舟云学术

Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Fox Proinnsias G.¹²,Schiavetti Francesca¹,Rappuoli Rino¹,McLoughlin Rachel M.²,Bagnoli Fabio¹

Affiliation:

1. GSK, Siena, Italy

2. Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

Abstract

Staphylococcus aureus is one of the largest health care threats faced by humankind, with a reported mortality rate within the United States greater than that of HIV/AIDS, tuberculosis, and viral hepatitis combined. One of the defining features of S. aureus as a human pathogen is its ability to evade and impair the human immune response through expression of staphylococcal protein A.

Funder

GlaxoSmithKline Biologicals SA and Trinity College Dublin

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00899-21

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