Sera of Individuals Chronically Infected with Hepatitis B Virus (HBV) Contain Diverse RNA Types Produced by HBV Replication or Derived from Integrated HBV DNA-Reference-Cited by-同舟云学术

Sera of Individuals Chronically Infected with Hepatitis B Virus (HBV) Contain Diverse RNA Types Produced by HBV Replication or Derived from Integrated HBV DNA

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zaiets Igor¹,Gunewardena Sumedha²,Menne Stephan³,Weinman Steven A.⁴,Gudima Severin O.¹^ORCID

Affiliation:

1. Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

2. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

3. Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

4. Department of Internal Medicine, Division of Gastroenterology, Liver Center, University of Kansas Medical Center, Kansas City, Kansas, USA

Abstract

The presence of integrant-derived RNAs (id-RNAs) and 5′-human-HBV-3′ transcripts derived from integrated hepatitis B virus (HBV) DNA in sera was demonstrated for the first time. Thus, sera of individuals chronically infected with HBV contained both replication-derived and integrant-transcribed HBV RNAs.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01950-22

Reference71 articles.

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