Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility

Author:

Farrukee R.12,Zarebski A. E.3,McCaw J. M.3456,Bloom J. D.7,Reading P. C.12,Hurt A. C.12

Affiliation:

1. WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

2. Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

3. School of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia

4. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia

5. Victorian Infectious Diseases Reference Laboratory Epidemiology Unit, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

6. Infection and Immunity theme, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia

7. Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

Treatment options for influenza B virus infections are limited to neuraminidase inhibitors (NAIs), which block the neuraminidase (NA) glycoprotein on the virion surface. The development of NAI resistance would therefore result in a loss of antiviral treatment options for influenza B virus infections.

Funder

Department of Health, Australian Government

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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