Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice-Reference-Cited by-同舟云学术

Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Amblard Franck¹,Boucle Sebastien¹,Bassit Leda¹,Cox Bryan¹,Sari Ozkan¹,Tao Sijia¹,Chen Zhe¹,Ozturk Tugba¹,Verma Kiran¹,Russell Olivia¹,Rat Virgile²,de Rocquigny Hugues²,Fiquet Oriane³⁴,Boussand Maud³⁴,Di Santo James³⁴,Strick-Marchand Helene³⁴,Schinazi Raymond F.¹

Affiliation:

1. Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

2. Morphogenèse et Antigénicité du VIH et des Virus des Hépatites, Inserm – U1259 MAVIVH, Hôpital Bretonneau, Tours, France

3. Innate Immunity Unit, Institut Pasteur, Paris, France

4. Inserm U1223, Paris, France

Abstract

Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of covalently closed circular DNA (cccDNA)—the viral minichromosome—in the nucleus of hepatocytes. Current nucleoside analogs and interferon therapies rarely clear cccDNA, requiring lifelong treatment.

Funder

European Commission Seventh Framework Programme PATHCo

HHS | National Institutes of Health

Agence Nationale de Recherches sur le Sida et les Hépatites Virales

Emory University | Center for AIDS Research, Emory University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01701-19

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