Neospora caninum Dense Granule Protein 7 Regulates the Pathogenesis of Neosporosis by Modulating Host Immune Response

Author:

Nishikawa Yoshifumi1,Shimoda Naomi1,Fereig Ragab M.123,Moritaka Tomoya1,Umeda Kousuke1,Nishimura Maki1,Ihara Fumiaki1,Kobayashi Kaoru1,Himori Yuu1,Suzuki Yutaka4,Furuoka Hidefumi5

Affiliation:

1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

2. Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

3. Department of Animal Medicine, Faculty of Veterinary Medicine, South Valley University, Qena City, Qena, Egypt

4. Graduate School of Frontier Science, The University of Tokyo, Kashiwa, Chiba, Japan

5. Division of Pathobiological Science, Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

Abstract

Neospora caninum invades and replicates in a broad range of host species and cells within those hosts. The effector proteins exported by Neospora induce its pathogenesis by modulating the host immunity. We show that most of the transcriptomic effects in N. caninum -infected cells depend upon the activity of NcGRA7. A deficiency in NcGRA7 reduced the virulence of the parasite in mice. This study demonstrates the importance of NcGRA7 in the pathogenesis of neosporosis.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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