In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to IS Aba1 -Mediated Overexpression of the Natural bla OXA-66 Oxacillinase Gene-Reference-Cited by-同舟云学术

In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to IS Aba1 -Mediated Overexpression of the Natural bla OXA-66 Oxacillinase Gene

Published:2009-06 Issue:6 Volume:53 Page:2657-2659
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Figueiredo Samy¹,Poirel Laurent¹,Croize Jacques²,Recule Christine²,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France

2. Département de Bactériologie-Microbiovigilance, DAI Pôle de Biologie, Grenoble, France

Abstract

ABSTRACT Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the IS Aba1 element upstream of the naturally occurring bla OXA-66 carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla OXA-66 gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01663-08

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