Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern-Reference-Cited by-同舟云学术

Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern

Published:2022-12-20 Issue:12 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kim Tai Young¹^ORCID,Jeon Sangeun²,Ko Meehyun²,Du Young Eun³,Son So-Ri⁴,Jang Dae Sik³⁴,Kim Seungtaek²,Lee C. Justin¹^ORCID

Affiliation:

1. Center for Cognition and Sociality, Institute for Basic Science, Daejeon, South Korea

2. Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, South Korea

3. Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, South Korea

4. Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, South Korea

Abstract

Several plant-derived natural products with anti-SARS-CoV-2 activity have been evaluated for the potential to serve as chemotherapeutic agents for the treatment of COVID-19. Codonopsis lanceolata (CL) has long been used as a medicinal herb in East Asian countries to treat inflammatory diseases of the respiratory system but its antiviral activity has not been investigated so far. Here, we showed that CL extract and its active compound lancemaside A (LA) displayed potent inhibitory activity against SARS-CoV-2 infection using a pseudotyped SARS-CoV-2 entry assay system.

Funder

Institute for Basic Science (IBS), South Korea

Ministry of Science and ICT, South Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01201-22

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