1. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; Genomics Research Center, Academia Sinica, Taipei, Taiwan; Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan; Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan; and Division of Biomedical Sciences, University of California, Riverside, California, USA