Antimicrobial Resistance Conferred by OXA-48 β-Lactamases: Towards a Detailed Mechanistic Understanding-Reference-Cited by-同舟云学术

Antimicrobial Resistance Conferred by OXA-48 β-Lactamases: Towards a Detailed Mechanistic Understanding

Published:2021-05-18 Issue:6 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hirvonen Viivi H. A.¹²^ORCID,Spencer James³^ORCID,van der Kamp Marc W.¹²^ORCID

Affiliation:

1. School of Biochemistry, University of Bristol, Bristol, United Kingdom

2. Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol, United Kingdom

3. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

Abstract

OXA-48-type β-lactamases are now routinely encountered in bacterial infections caused by carbapenem-resistant Enterobacterales . These enzymes are of high and growing clinical significance due to the importance of carbapenems in treatment of health care-associated infections by Gram-negative bacteria, the wide and increasing dissemination of OXA-48 enzymes on plasmids, and the challenges posed by their detection.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00184-21

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