First Report of Sudden Death Due to Myocarditis Caused by Adenovirus Serotype 3

Author:

Treacy Ann1,Carr Michael J.2,Dunford Linda23,Palacios Gustavo4,Cannon Gemma A.2,O'Grady Anthony5,Moran Julie2,Hassan Jaythoon2,Loy Aisling2,Connell Jeff2,Devaney Deirdre1,Kelehan Peter6,Hall William W.23

Affiliation:

1. Department of Histopathology, Children's University Hospital, Temple Street, Dublin 1, Ireland

2. National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland

3. Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland

4. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York

5. Department of Histopathology, Beaumont Hospital and Royal College of Surgeons, Dublin, Ireland

6. National Maternity Hospital, Holles Street, Dublin 2, Ireland

Abstract

ABSTRACT Myocarditis is a rare cause of sudden death in childhood. We describe the sudden death of a child from viral myocarditis, which we demonstrate was likely caused by an uncontrolled inflammatory response to a disseminated adenovirus serotype 3 infection originating in the tonsil.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference20 articles.

1. Aretz, H. T. 1987. Myocarditis: the Dallas criteria. Hum. Pathol. 18 : 619-624.

2. Baboonian, C., and W. McKenna. 2003. Eradication of viral myocarditis: is there hope? J. Am. Coll. Cardiol. 42 : 473-476.

3. Bowles, N. E., J. Ni, D. L. Kearney, M. Pauschinger, H. P. Schultheiss, R. McCarthy, J. Hare, J. T. Bricker, K. R. Bowles, and J. A. Towbin. 2003. Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults. J. Am. Coll. Cardiol. 42 : 466-472.

4. Molecular Identification of Adenoviruses in Clinical Samples by Analyzing a Partial Hexon Genomic Region

5. Dennert, R., H. J. Crijns, and S. Heymans. 2008. Acute viral myocarditis. Eur. Heart J. 29 : 2073-2082.

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