Identification and Characterization of Nanobodies from a Phage Display Library and Their Application in an Immunoassay for the Sensitive Detection of African Swine Fever Virus

Author:

Zhao Yaru12,Yang Jifei1ORCID,Niu Qingli1ORCID,Wang Jinming1,Jing Mengyao1,Guan Guiquan1,Liu Meng3,Luo Jianxun1,Yin Hong14,Liu Zhijie15

Affiliation:

1. African Swine Fever Regional Laboratory of China (Lanzhou), State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, People’s Republic of China

2. China Agricultural VET. BIO, Science and Technology Co., Ltd., Lanzhou, People’s Republic of China

3. Animal Husbandry and Veterinary Bureau of Dingxi City, Dingxi, Gansu, People’s Republic of China

4. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, People’s Republic of China

5. Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, People’s Republic of China

Abstract

African swine fever (ASF) is one of the most lethal and devastating diseases of domestic and wild swine. The continual spread and frequent outbreaks of ASF have seriously threatened the pig and pig-related industries, causing great socioeconomic losses at unprecedented proportions.

Funder

MOST | National Natural Science Foundation of China

Natural Science Foundation of Gansu Province

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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