Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing for Pediatric Infectious Diseases-Reference-Cited by-全球学者库

Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing for Pediatric Infectious Diseases

Published:2023-06-20 Issue:6 Volume:61 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Zhu Yunqian¹,Gan Mingyu²³,Ge Mengmeng¹,Dong Xinran²³,Yan Gangfeng⁴,Zhou Qinhua⁵,Yu Hui⁶,Wang Xiaochuan⁵,Cao Yun¹,Lu Guoping⁴,Wu Bingbing²³^ORCID,Zhou Wenhao¹²³⁷

Affiliation:

1. Department of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

2. Center for Molecular Medicine, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

3. Key Laboratory of Birth Defects, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

4. Department of Critical Care Medicine, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

5. Department of Clinical Immunology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

6. Department of Infectious Diseases, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

7. Key Laboratory of Neonatal Diseases, Ministry of Health, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China

Abstract

Metagenomic next-generation sequencing (mNGS) has shown promise in the diagnosis of infectious diseases in adults, while its efficacy in pediatric infections remains uncertain. We performed a retrospective analysis of 1,493 mNGS samples from pediatric patients with blood, central nervous system, and lower respiratory tract infections.

Funder

MOST | National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

China Primary Health Care Foundation

Shanghai Hospital Development Center

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.00115-23

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