African Swine Fever Virus Gene B117L Encodes a Small Protein Endowed with Low-pH-Dependent Membrane Permeabilizing Activity

Author:

Gladue Douglas P.1ORCID,Gomez-Lucas Lidia2,Largo Eneko23,Velazquez-Salinas Lauro1,Ramirez-Medina Elizabeth1,Torralba Johana2,Queralt Maria4,Alcaraz Antonio4,Nieva Jose L.2,Borca Manuel V.1

Affiliation:

1. Plum Island Animal Disease Center, ARS, USDA, Greenport, New York, USA

2. Instituto Biofisika (CSIC-UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country, Bilbao, Spain

3. Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain

4. Laboratory of Molecular Biophysics. Department of Physics. University Jaume I, Castellón, Spain

Abstract

ASFV is responsible for an extensively distributed pandemic causing important economic losses in the pork industry in Eurasia. The development of countermeasures is partially limited by the insufficient knowledge regarding the function of the majority of the more than 150 genes present on the virus genome.

Funder

Basque Goverment

National Pork Board

Foundation for Food and Agriculture Research

USDA | Agricultural Research Service

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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