Population Pharmacokinetic Analysis of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis-Reference-Cited by-同舟云学术

Population Pharmacokinetic Analysis of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis

Published:2023-02-23 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abdelgawad Noha¹^ORCID,Tshavhungwe Mvuwo (Phophi)²,Rohlwink Ursula²³,McIlleron Helen¹⁴^ORCID,Abdelwahab Mahmoud T.¹,Wiesner Lubbe¹,Castel Sandra¹,Steele Chanel¹,Enslin Johannes (Nico)²,Thango Nqobile Sindiswa²,Denti Paolo¹^ORCID,Figaji Anthony²³

Affiliation:

1. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

2. Division of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa

3. Neuroscience Institute, University of Cape Town, Cape Town, South Africa

4. Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Abstract

Limited knowledge is available on the pharmacokinetics of rifampicin in children with tuberculous meningitis (TBM) and its penetration into brain tissue, which is the site of infection. In this analysis, we characterize the distribution of rifampicin in cerebrospinal fluid (CSF), lumbar (LCSF) and ventricular (VCSF), and brain extracellular fluid (ECF).

Funder

South African Research Chairs

Ernest Oppenheimer Memorial Trust

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | Fogarty International Center

HHS | NIH | National Institute of Allergy and Infectious Diseases

International Maternal Pediatric Adolescent AIDS Clinical Trials Network

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01474-22

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