TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria

Author:

Pandya Yash1,Marta Alexander1,Barateiro André2,Bandeira Carla Letícia2,Dombrowski Jamille Gregório2ORCID,Costa João1,Marinho Cláudio Romero Farias2,Penha-Gonçalves Carlos1ORCID

Affiliation:

1. Instituto Gulbenkian de Ciência, Oeiras, Portugal

2. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, São Paulo, São Paulo, Brazil

Abstract

Pregnancy-associated malaria is often associated with adverse pregnancy outcomes. Placental circulatory impairments are an intriguing and unsolved component of malaria pathophysiology.

Funder

NOS ALIVE

March of Dimes

Sao Paulo Research Foundation

ONEIDA

CONGENTO

Fundacao para Ciencia e Tecnologia

São Paulo Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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