Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2

Author:

Bergelson J M1,St John N1,Kawaguchi S1,Chan M1,Stubdal H1,Modlin J1,Finberg R W1

Affiliation:

1. Laboratory of Infectious Disease, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.

Abstract

Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference19 articles.

1. Interrelationships among echovirus types 1, 8, and 12;Berg G.;J. Bacteriol.,1961

2. Bergelson J. M. Chan and R. W. Finberg. Unpublished data.

3. The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms;Bergelson J. M.;J. Clin. Invest.,1993

4. Identification of the integrin VLA-2 as a receptor for echovirus 1;Bergelson J. M.;Science,1992

5. Cherry J. 1983. Enteroviruses p. 290-334. In J. Remington and J. Klein (ed.) Infectious diseases of the fetus and newborn infant 2nd ed. W. B. Saunders New York.

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