Phenotypic and Functional Characteristics of a Novel Influenza Virus Hemagglutinin-Specific Memory NK Cell-Reference-Cited by-同舟云学术

Phenotypic and Functional Characteristics of a Novel Influenza Virus Hemagglutinin-Specific Memory NK Cell

Published:2021-05-24 Issue:12 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zheng Jian¹²,Wen Liyan¹,Yen Hui-Ling³^ORCID,Liu Ming⁴,Liu Yinping¹,Teng Ooiean³,Wu Wing-Fung³,Ni Ke¹,Lam Kowk-Tai¹,Huang Chunyu¹,Yang Jiashuang¹,Lau Yu-Lung¹,Perlman Stanley²^ORCID,Peiris Malik³^ORCID,Tu Wenwei¹^ORCID

Affiliation:

1. Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong

2. Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA

3. School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong

4. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Abstract

In this study, we demonstrate a novel hemagglutinin (HA)-specific NKp46 + NKG2A + NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased gamma interferon (IFN-γ) on reencountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.

Funder

Research Grants Council, University Grants Committee

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00165-21

Reference71 articles.

1. Influenza A viruses: new research developments

2. Influenza

3. Memory responses of innate lymphocytes and parallels with T cells