Newly Discovered Antimicrobial Peptide Scyampcin <sub>44–63</sub> from Scylla paramamosain Exhibits a Multitargeted Candidacidal Mechanism <i>In Vitro</i> and Is Effective in a Murine Model of Vaginal Candidiasis-Reference-Cited by-同舟云学术

Newly Discovered Antimicrobial Peptide Scyampcin _44–63 from Scylla paramamosain Exhibits a Multitargeted Candidacidal Mechanism In Vitro and Is Effective in a Murine Model of Vaginal Candidiasis

Published:2023-06-15 Issue:6 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhou Ying¹^ORCID,Meng Xiangyu¹,Chen Fangyi¹²,Xiong Ming¹²,Zhang Weibin¹,Wang Ke-Jian¹²^ORCID

Affiliation:

1. State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China

2. State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China

Abstract

The emergence of azole-resistant and biofilm-forming Candida spp. contributes to the constantly increasing incidence of vulvovaginal candidiasis. It is imperative to explore new antifungal drugs or potential substituents, such as antimicrobial peptides, to alleviate the serious crisis caused by resistant fungi.

Funder

MOST | National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00022-23

Reference45 articles.

1. Vulvovaginal Candidiasis: A Current Understanding and Burning Questions

2. Vulvovaginal candidosis

3. In Vivo Applicability of Neosartorya fischeri Antifungal Protein 2 (NFAP2) in Treatment of Vulvovaginal Candidiasis

4. Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistantCandida albicans

5. Membrane-Interacting Antifungal Peptides