Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs

Author:

Zhao Shanshan1,Wu Xiaowei2,Tan Zhihong1,Ren Yi3,Li Lian1,Ou Junxian3,Lin Ying14,Song Hongbin5,Feng Liqiang6,Seto Donald7,Wu Jianguo3,Zhang Qiwei23ORCID,Rong Zhili148ORCID

Affiliation:

1. Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou 510515, China

2. BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China

3. Key Laboratory of Ministry of Education for Viral Pathogenesis & Infection Prevention and Control, Institute of Medical Microbiology, Jinan University, Guangzhou, China

4. Experimental Education/Administration Center, School of Basic Medical Science, Southern Medical University, Guangzhou, China

5. Chinese PLA Center for Disease Control and Prevention, Beijing, China

6. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

7. Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, Virginia, USA

8. Dermatology Hospital, Southern Medical University, Guangzhou, China

Abstract

Human adenovirus (HAdV) infections are a major threat worldwide. HAdV-3 is one of the most predominant respiratory pathogen types found in children.

Funder

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research Foundation

MOST | National Key Research and Development Program of China

MOE | Fundamental Research Funds for the Central Universities

GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province

The R&D Program of Guangzhou Laboratory

National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Adenoviruses;Molecular Medical Microbiology;2024

2. Alveolar Type 2 Epithelial Cell Organoids: Focus on Culture Methods;Biomedicines;2023-11-12

3. Nanoblades allow high-level genome editing in murine and human organoids;Molecular Therapy - Nucleic Acids;2023-09

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