Affiliation:
1. Janssen Research Foundation, Beerse, Belgium.
Abstract
A variety of chemically different compounds inhibit the replication of several serotypes of rhinoviruses (common-cold viruses). We noticed that one of these antiviral compounds, WIN 51711, had an antiviral spectrum clearly distinctive from a consensus spectrum or other capsid-binding compounds, although all of them were shown to share the same binding site. A systematic evaluation of all known rhinovirus capsid-binding compounds against all serotyped rhinoviruses was therefore initiated. Multivariate analysis of the results revealed the existence of two groups of rhinoviruses, which we will call antiviral groups A and B. The differential sensitivity of members of these groups to antiviral compounds suggests the existence of a dimorphic binding site. The antiviral groups turned out to be a reflection of a divergence of rhinovirus serotypes on a much broader level. Similarities in antiviral spectra were highly correlated with sequence similarities, not only of amino acids lining the antiviral compound-binding-site, but also of amino acids of the whole VP1 protein. Furthermore, analysis of epidemiological data indicated that group B rhinoviruses produced more than twice as many clinical infections per serotype than group A rhinoviruses did. Rhinoviruses belonging to the minor receptor group were without exception all computed to lie in the same region of antiviral group B.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference25 articles.
1. Many rhinovirus serotypes share the same cellular receptor;Abraham G.;Virology,1984
2. In vitro activity of R 61837, a new antirhinovirus compound;Andries K.;Arch. Virol.,1988
3. Lack of quantitative correlation between inhibition of replication of rhinoviruses by an antiviral drug and their stabilization;Andries K.;Arch. Virol.,1989
4. RMI 15,731(1-[5-tetradecyloxy-2-furanyl]-ethanone), a new antirhinovirus compound;Ash R. J.;Antimicrob. Agents Chemother.,1979
5. 4',6-Dichloroflavan (BW683C), a new anti-rhinovirus compound;Bauer D. J.;Nature (London),1981
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