Antimicrobial Susceptibility and Mutations Involved in Clarithromycin Resistance in Helicobacter pylori Isolates from Patients in the Western Central Region of Colombia-Reference-Cited by-同舟云学术

Antimicrobial Susceptibility and Mutations Involved in Clarithromycin Resistance in Helicobacter pylori Isolates from Patients in the Western Central Region of Colombia

Published:2009-09 Issue:9 Volume:53 Page:4022-4024
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Álvarez Adalucy¹,Moncayo José Ignacio¹,Santacruz Jorge Javier¹,Santacoloma Mario²,Corredor Luisa Fernanda¹,Reinosa Elizabeth¹

Affiliation:

1. Universidad Tecnológica de Pereira, Centro de Biología Molecular y Biotecnología, Laboratorio de Microbiología y Parasitología, Pereira, Colombia

2. Universidad de Caldas, Departamento Clínico Quirúrgico, Manizales, Colombia

Abstract

ABSTRACT Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our results indicate that metronidazole should not be included in the empirical treatment of H. pylori infection in this region.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00145-09

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