Chromosome-Protein Interactions in Polyomavirus Virions-Reference-Cited by-同舟云学术

Chromosome-Protein Interactions in Polyomavirus Virions

Published:2004-01 Issue:1 Volume:78 Page:513-519
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Carbone Mariarosaria¹,Ascione Giuseppe¹,Chichiarelli Silvia²,Garcia Marie-Isabelle¹,Eufemi Margherita²,Amati Paolo¹

Affiliation:

1. Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare

2. Dipartimento di Scienze Biochimiche “A. Rossi Fanelli,” Università di Roma “La Sapienza,” 00161 Rome, Italy

Abstract

ABSTRACT In this work, we sought to determine whether the components of the murine polyomavirus capsid establish specific interactions with the minichromosome encapsidated into the mature viral particles by using the cis -diamminedichloroplatinum(II) cross-linking reagent. Our data indicated that VP1, but not minor capsid proteins, interacts with the viral genome in vivo. In addition, semiquantitative PCR assays performed on cross-linked DNA complexes revealed that VP1 binds to all regions of the viral genome but significantly more to the regulatory region. The implications of such an interaction for viral infectivity are discussed.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.1.513-519.2004

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