Clinical Performance of SARS-CoV-2 Molecular Tests

Author:

Green Daniel A.1ORCID,Zucker Jason2,Westblade Lars F.34,Whittier Susan1,Rennert Hanna3,Velu Priya3,Craney Arryn3,Cushing Melissa3,Liu Dakai5,Sobieszczyk Magdalena E.2,Boehme Amelia K.6,Sepulveda Jorge L.1ORCID

Affiliation:

1. Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, New York, USA

2. Division of Infectious Diseases, Department of Internal Medicine, Columbia University Irving Medical Center, New York, New York, USA

3. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

4. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA

5. Department of Pathology and Clinical Laboratories, NewYork-Presbyterian Queens Hospital, Queens, New York, USA

6. Department of Epidemiology and Neurology, Columbia University Irving Medical Center, New York, New York, USA

Abstract

Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the clinical performance of these tests is still poorly understood, particularly with regard to disease course, patient-specific factors, and viral shedding. From 10 March to 1 May 2020, NewYork-Presbyterian laboratories performed 27,377 SARS-CoV-2 molecular assays from 22,338 patients. Repeat testing was performed for 3,432 patients, of which 2,413 had initial negative and 802 had initial positive results.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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