Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use

Author:

Slack M. P. E.1ORCID,Cripps A. W.12,Grimwood K.1234,Mackenzie G. A.567,Ulanova M.8

Affiliation:

1. School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Queensland, Australia

2. Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland, Australia

3. Department of Infectious Diseases, Gold Coast Health, Southport, Queensland, Australia

4. Department of Paediatrics, Gold Coast Health, Southport, Queensland, Australia

5. London School of Hygiene and Tropical Medicine, London, United Kingdom

6. Medical Research Council Unit, The Gambia at LSHTM, Fajara, The Gambia

7. Murdoch Children’s Research Institute, Parkville, Victoria, Australia

8. Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada

Abstract

Haemophilus influenzae serotype b (Hib) was previously the most common cause of bacterial meningitis and an important etiologic agent of pneumonia in children aged <5 years. Its major virulence factor is the polyribosyl ribitol phosphate (PRP) polysaccharide capsule.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Reference237 articles.

1. Moxon ER. 1995. Haemophilus influenzae, p 2039–2050. In Mandell GL, Bennett JE, Dolin R (ed), Mandell, Douglas and Bennett's principles and practice of infectious disease, 4th ed, vol 2. Churchill Livingstone, New York, NY.

2. The Protective Level of Serum Antibodies to the Capsular Polysaccharide of Haemophilus influenzae Type b

3. Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory;Käyhty H;Pediatrics,1984

4. The Protective Level of Serum Antibodies to the Capsular Polysaccharide of Haemophilus influenzae type b

5. Worldwide Haemophilus influenzae Type b Disease at the Beginning of the 21st Century: Global Analysis of the Disease Burden 25 Years after the Use of the Polysaccharide Vaccine and a Decade after the Advent of Conjugates

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