Life with Bacterial Mechanosensitive Channels, from Discovery to Physiology to Pharmacological Target

Author:

Blount Paul1,Iscla Irene1

Affiliation:

1. Department of Physiology, UT Southwestern Medical Center, Dallas, Texas, USA

Abstract

General principles in biology have often been elucidated from the study of bacteria. This is true for the bacterial mechanosensitive channel of large conductance, MscL, the channel highlighted in this review. This channel functions as a last-ditch emergency release valve discharging cytoplasmic solutes upon decreases in osmotic environment.

Funder

HHS | NIH | National Institute of General Medical Sciences

Welch Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

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