Macrolide-Resistant Mycoplasma pneumoniae in the United States as Determined from a National Surveillance Program

Author:

Waites K. B.1,Ratliff A.1,Crabb D. M.1,Xiao L.2,Qin X.3,Selvarangan R.4,Tang Y.-W.5ORCID,Zheng X.6ORCID,Dien Bard J.7,Hong T.8,Prichard M.9,Brooks E.10,Dallas S.11,Duffy L.1,Mixon E.9,Fowler K. B.9,Atkinson T. P.9

Affiliation:

1. Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Department of Laboratory Medicine and Pathology, Seattle Children’s Hospital, Seattle, Washington, USA

4. Children’s Mercy Hospital, Kansas City, Missouri, USA

5. Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, New York, USA

6. Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA

7. Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

8. Department of Pathology, Hackensack University Medical Center, Hackensack, New Jersey, USA

9. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA

10. Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA

11. Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

Abstract

There are sparse data to indicate the extent that macrolide-resistant Mycoplasma pneumoniae (MRMp) occurs in the United States or its clinical significance. Between 2015 and 2018, hospitals in 8 states collected and stored respiratory specimens that tested positive for M. pneumoniae and sent them to the University of Alabama at Birmingham, where real-time PCR was performed for detection of 23S rRNA mutations known to confer macrolide resistance. MRMp was detected in 27 of 360 specimens (7.5%).

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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