Microbiological characterization of <i>Pneumocystis jirovecii</i> pneumonia using quantitative PCR from nasopharyngeal specimens: a retrospective study in a Canadian province from 2019 to 2023-Reference-Cited by-同舟云学术

Microbiological characterization of Pneumocystis jirovecii pneumonia using quantitative PCR from nasopharyngeal specimens: a retrospective study in a Canadian province from 2019 to 2023

Published:2023-11-21 Issue:11 Volume:61 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Lieu Anthony¹²^ORCID,Lee Todd C.¹,Lawandi Alexander¹²^ORCID,Tellier Raymond¹²,Cheng Matthew P.¹²,Dufresne Philippe J.³^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, McGill University Health Centre , Montréal, Québec, Canada

2. Division of Medical Microbiology, Department of Laboratory Medicine, McGill University Health Centre , Montréal, Canada

3. Laboratoire de santé publique du Québec, Institut national de santé publique du Québec , Sainte-Anne-de-Bellevue, Québec, Canada

Abstract

ABSTRACT Bronchoalveolar lavage is usually employed for molecular diagnosis of Pneumocystis jirovecii but requires a specialized procedure. By contrast, nasopharyngeal (NP) specimens are easily obtained. In this retrospective study of 35 patients with paired NP and bronchoscopy specimens, NP specimens had a 100% negative percent agreement (95% CI 80.5–100) but only 72.2% positive percent agreement (95% CI 46.5–90.3).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.00913-23

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