Pharmacokinetic Model of Tenofovir and Emtricitabine and Their Intracellular Metabolites in Patients in the ANRS 134-COPHAR 3 Trial Using Dose Records
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Published:2023-05-17
Issue:5
Volume:67
Page:
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ISSN:0066-4804
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Container-title:Antimicrobial Agents and Chemotherapy
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language:en
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Short-container-title:Antimicrob Agents Chemother
Author:
Bertrand Julie1ORCID, Barrail-Tran Aurélie23ORCID, Fayette Lucie1, Savic Rada4ORCID, Goujard Cécile56, Teicher Elina5, Barau Caroline7, Pruvost Alain8, Taburet Anne-Marie23, Mentré France1, Verstuyft Céline69, Barrail-Tran A., Brunet A., Commoy M.-J., Couffin-Cadiergues S., Descamps D., Duval X., Goujard C., Le Guellec C., Mentré F., Nembot G., Taburet A.-M., Vrijens B., Ajana ••, Aissi ••, Baclet ••, Besnier ••, Bollens ••, Boulanger ••, Brochier ••, Brunet ••, Chaix ••, Ciuchete ••, Ghosn ••, Duval ••, Ferret ••, Ferret ••, Gaubin ••, Goujard ••, Girard ••, Kouadio ••, Lupin ••, Parienti ••, Ajana ••, Parrinello ••, Poinçon de la Blanchardière ••, May ••, Marien ••, Medintzeff ••, Metivier ••, Mole ••, Molina ••, Nau ••, Ouazene ••, Pintado ••, Quertainmont ••, Ramani ••, Rami ••, Sellier ••, Simon ••, Talbi ••, Thoirain ••, Verdon ••, Trépo ••, Wassoumbou ••, Yazdanpanah ••, Barrail-Tran ••, Gagneux ••, Delhotal ••, Hoizey ••, Houdret ••, Leguellec ••, Peytavin ••, Poirier ••, Sauvageon ••, Taburet ••, André ••, Soulié ••, Calvez ••, Morand-Joubert ••, Harchi ••, Bocket ••, Mourez ••, Palmer ••, Pallier ••, Deschamps ••, Mazeron ••, Bolmann ••, Storto ••, Thanh Thuy ••, Nembot G., Unal G., Mentré F., Mentré F., Panhard X., Savic R., Vrijens B.
Affiliation:
1. UMR 1137, IAME, INSERM, Université Paris Cité, Paris, France 2. AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin-Bicêtre, France 3. UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM, Université Paris Sud, Paris, France 4. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA 5. AP-HP, Hôpital Bicêtre, Service de médecine interne et d’immunologie clinique, Le Kremlin-Bicêtre, France 6. CESP, Team Epidémiologie Clinique, INSERM UMR 1018, Faculté de Médecine, Univ Paris-Saclay, Le Kremlin Bicêtre, France 7. AP-HP, Hôpital Henri Mondor, Plateforme de Ressources Biologiques, Créteil, France 8. Département Médicaments et Technologies pour la Santé, SPI, CEA, INRAE, Université Paris Saclay, Paris, France 9. AP-HP, Hôpital Bicêtre, Service de génétique moléculaire et pharmacogénétique, Le Kremlin-Bicêtre, France
Abstract
Tenofovir (TFV) and emtricitabine (FTC) are part of the recommended highly active antiretroviral therapy (ART). Both molecules show a large interindividual pharmacokinetic (PK) variability.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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