Swine H1N1 Influenza Virus Variants with Enhanced Polymerase Activity and HA Stability Promote Airborne Transmission in Ferrets-Reference-Cited by-全球学者库

Swine H1N1 Influenza Virus Variants with Enhanced Polymerase Activity and HA Stability Promote Airborne Transmission in Ferrets

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hu Meng¹,Jones Jeremy C.¹,Banoth Balaji¹,Ojha Chet Raj¹,Crumpton Jeri Carol¹,Kercher Lisa¹,Webster Robert G.¹^ORCID,Webby Richard J.¹²,Russell Charles J.¹²^ORCID

Affiliation:

1. Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

2. Department of Microbiology, Immunology & Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA

Abstract

Diverse IAVs circulate in animals, yet few acquire the viral traits needed to start a human pandemic. A stabilized HA and mammalian-adapted polymerase have been shown to promote the adaptation of IAVs to humans and ferrets (the gold-standard model for IAV replication, pathogenicity, and transmissibility).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00100-22

Reference92 articles.

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