High Risk of QT Interval Prolongation and Torsades de Pointes Associated with Intravenous Quinidine Used for Treatment of Resistant Malaria or Babesiosis-Reference-Cited by-同舟云学术

High Risk of QT Interval Prolongation and Torsades de Pointes Associated with Intravenous Quinidine Used for Treatment of Resistant Malaria or Babesiosis

Published:2012-08 Issue:8 Volume:56 Page:4495-4499
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wroblewski Heather A.¹,Kovacs Richard J.²³,Kingery Joanna R.⁴,Overholser Brian R.¹²,Tisdale James E.¹²

Affiliation:

1. Department of Pharmacy Practice, College of Pharmacy, Purdue University, Indianapolis, Indiana, USA

2. Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA

3. Krannert Institute of Cardiology, Indianapolis, Indiana, USA

4. the Department of Pharmacy, Indiana University Health Methodist Hospital, Indianapolis, Indiana, USA

Abstract

ABSTRACTCardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation. Intravenous quinidine doses for resistant malaria are 2 to 3 times higher than those used for arrhythmias. Among 6 patients receiving quinidine for malaria or babesiosis, 4 developed QT interval prolongation and 2 experienced TdP. Clinicians should be aware that recommended doses of quinidine for malaria carry a high TdP risk.

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.06396-11

Reference27 articles.

1. Continuous intravenous quinidine infusion for the treatment of atrial fibrillation or flutter: a case series;Allen LaPointe NM;Am. Heart J.,2000

2. Torsade de pointes due to quinidine: observations in 31 patients;Bauman JL;Am. Heart J.,1984

3. An analysis of time relationships of the electrocardiogram;Bazett HC;Heart,1920

4. Delayed cardiotoxicity following quinine overdose: a case report;Bodenhamer JE;J. Emerg. Med.,1993

5. Severe cardiac toxicity due to halofantrine: importance of underlying heart disease;Bouchaud O;J. Travel Med.,2002

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