Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody-Reference-Cited by-同舟云学术

Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Peng Shiwen¹,Ferrall Louise¹,Gaillard Stephanie²³,Wang Chenguang⁴,Chi Wei-Yu¹,Huang Chuan-Hsiang¹,Roden Richard B. S.¹²^ORCID,Wu T.-C.¹²³^ORCID,Chang Yung-Nien⁵,Hung Chien-Fu¹²³^ORCID

Affiliation:

1. Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA

2. Department of Oncology, The Johns Hopkins University, Baltimore, Maryland, USA

3. Department of Obstetrics and Gynecology, The Johns Hopkins University, Baltimore, Maryland, USA

4. Department of Oncology Biostatistics, The Johns Hopkins University, Baltimore, Maryland, USA

5. Papivax Biotech Inc., Taipei, Taiwan, Republic of China

Abstract

Persistent expression of high-risk human papillomavirus (HPV) E6 and E7 is an obligate driver for several human malignancies, including cervical cancer, wherein HPV16 and HPV18 are the most common types. PD-1 antibody immunotherapy helps a subset of cervical cancer patients, and its efficacy might be improved by combination with active vaccination against E6 and/or E7.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03224-20

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