Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes-Reference-Cited by-全球学者库

Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes

Published:1999-02 Issue:2 Volume:19 Page:1479-1485
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Bertram M. J.¹,Bérubé N. G.¹,Hang-Swanson X.¹,Ran Q.¹,Leung J. K.¹,Bryce S.²,Spurgers K.¹,Bick R. J.³,Baldini A.⁴,Ning Y.⁵,Clark L. J.²,Parkinson E. K.²,Barrett J. C.⁶,Smith J. R.¹⁷⁸⁹,Pereira-Smith O. M.¹⁷⁸⁹

Affiliation:

1. Roy M. and Phyllis Gough Huffington Center on Aging 1 and

2. Beatson Cancer Institute, Glasgow, Scotland 2 ;

3. Department of Pathology, The University of Texas Medical School, 3 Houston, Texas 77030;

4. Molecular and Human Genetics4 and Departments of

5. GeneCare, the Wilson Genetics Center, George Washington University Medical Center, Washington, D.C. 20037 5 ; and

6. Laboratory of Molecular Carcinogenesis, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina 277096

7. Divisions of Molecular Virology9 and

8. Cell Biology7 and

9. Medicine, 8 Baylor College of Medicine, and

Abstract

ABSTRACT Based on the dominance of cellular senescence over immortality, immortal human cell lines have been assigned to four complementation groups for indefinite division. Human chromosomes carrying senescence genes have been identified, including chromosome 4. We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence. MORF 4 is a member of a novel family of genes with transcription factor-like motifs. We present here the sequences of the seven family members, their chromosomal locations, and a partial characterization of the three members that are expressed. Elucidation of the mechanism of action of these genes should enhance our understanding of growth regulation and cellular aging.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.19.2.1479

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