Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs

Author:

Dhakal Santosh1ORCID,Klein Sabra L.12

Affiliation:

1. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

2. Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

Abstract

Influenza is a global public health problem. Current seasonal influenza vaccines have highly variable efficacy, and thus attempts to develop broadly protective universal influenza vaccines with durable protection are under way. While much attention is given to the virus-related factors contributing to inconsistent vaccine responses, host-associated factors are often neglected.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference150 articles.

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5. A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases

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