Controlled Human Infection Models To Accelerate Vaccine Development-Reference-Cited by-同舟云学术

Controlled Human Infection Models To Accelerate Vaccine Development

Published:2022-09-21 Issue:3 Volume:35 Page:
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

Choy Robert K. M.¹^ORCID,Bourgeois A. Louis¹,Ockenhouse Christian F.¹,Walker Richard I.¹,Sheets Rebecca L.²,Flores Jorge¹

Affiliation:

1. PATH, Center for Vaccine Innovation and Access, Seattle, Washington, USA

2. Grimalkin Partners, Silver Spring, Maryland, USA

Abstract

The timelines for developing vaccines against infectious diseases are lengthy, and often vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of protective efficacy. The application of controlled human challenge models of infection and disease at the appropriate stages of development could accelerate development of candidate vaccines and, in fact, has done so successfully in some limited cases.

Funder

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/cmr.00008-21

Reference929 articles.

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