Clinical and Analytical Performance of an Automated Serological Test That Identifies S1/S2-Neutralizing IgG in COVID-19 Patients Semiquantitatively-Reference-Cited by-同舟云学术

Clinical and Analytical Performance of an Automated Serological Test That Identifies S1/S2-Neutralizing IgG in COVID-19 Patients Semiquantitatively

Published:2020-08-24 Issue:9 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Bonelli Fabrizio¹^ORCID,Sarasini Antonella²,Zierold Claudia¹,Calleri Mariella¹,Bonetti Alice²³,Vismara Chiara⁴,Blocki Frank A.¹,Pallavicini Luca¹,Chinali Alberto¹,Campisi Daniela⁴,Percivalle Elena²,DiNapoli Anna Pia²³,Perno Carlo Federico⁴,Baldanti Fausto²³

Affiliation:

1. DiaSorin, S.p.A., Saluggia, Italy

2. Molecular Virology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy

3. Department of Clinical, Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy

4. Department of Laboratory Medicine, ASST Niguarda Hospital, University of Milan, Milan, Italy

Abstract

In the coronavirus (CoV) disease 2019 (COVID-19) pandemic, highly selective serological testing is essential to define exposure to severe acute respiratory syndrome CoV 2 (SARS-CoV-2). Many tests have been developed, yet with variable speeds to first results, and are of unknown quality, particularly when considering the prediction of neutralizing capacity. The LIAISON SARS-CoV-2 S1/S2 IgG assay was designed to measure antibodies against the SARS-CoV-2 native S1/S2 proteins in a standardized automated chemiluminescence assay.

Funder

DiaSorin

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01224-20

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